An alternative approach to antimalarial drugs: At the Siegel Lab Group, we have synthesized lead small molecules that are able to prevent parasites from invading and developing in hepatoma cell lines but which have no activity against blood stage P. Falciparum parasites.
Hello, friends! 👋 How’s everyone doing today? . To wrap up the NMR discussion we’ve been having over the past few days, I wanna talk about the complex splitting patterns. This is a little more advanced topic than regular splitting in NMR, so some instructors choose not to cover it in their class. This is still a very important topic, so you at least wanna know about it. 😅 . So, what’s the deal with those complex patterns? 🤨🤔 . First-order splitting occurs when the splitting constants between the hydrogens are the same or very similar. A typical H-H splitting constant J=7Hz. But sometimes, the constant differs. This is especially common in compounds with double bonds, triple bonds, aromatic rings, and occasionally around strongly electron-withdrawing groups. The constant also depends on the dihedral angle between the resonating hydrogens, so it sometimes differ from the “typical” value in sterically “locked” molecules. . We can illustrate this phenomenon with the vinyl group of vinyl acetate (in the picture). Here, due to the different splitting constants between the green, orange, and purple hydrogens, the splitting pattern no longer fits into the typical Pascal’s triangle shape. So, make sure you’re paying close attention to the signal shape when analyzing your NMR’s. For instance, the signal from the green hydrogen is not a quartet but a doubles of doublets! Thus, the n+1 rule doesn’t apply since it’s not a first-order splitting pattern. . Victor 👨🔬 @OChemTutor . . . . . #spectroscopy#nmr#hnmr . #organicchemistry#stem#ochem#orgo#chemistry#sutudy#instascience#biochemistry#premed#prevet#predental#chem#mcat#mcatstudying#mcatprep#nursingschool#studytips#studygram#studynotes#chemistrymajor#studymotivation#chemistryteacher#chemistrystudent#medstudent#cheatsheet#molecules#ochemtutor
I realized since starting this account that I have never formally introduced myself. Now that the account has reached 1000+ followers I think it is great time to do so. To everyone who doesnt know me, my name is Ali Mansour. Hello! Welcome to my chemistry page and thank you so much for taking an interest in the content I post 😊 I am 🇨🇦/🇱🇧 and am from Ottawa, Ontario. I did my BSc at uOttawa, MSc at McGill University in Montréal (will forever miss MTL 😭❤️) and am now pursuing a PhD back at uOttawa with Dr. Fabien Gagosz 👨🏻🔬📖 Our lab studies gold 💛 catalysis as it is applied to the synthesis of valuable heterocyclic scaffolds for medicinal chemistry 💉💊/interesting polycyclic frameworks which can be found in natural products 🌿🌺 Our lab is always looking for new students and volunteers, so if you are interested (local or abroad), please feel free to message me about it. When I started this account, I wasnt sure how it would work out. Eventually I found it growing steadily, and realized how much good it can do. Im passionate about organic chemistry, love talking about it, and love documenting research visually. Thanks again to everyone who has been following along with me on this journey, stay tuned for some awesome stuff to come! #chemistry#synthesis#organic#ochem#organicchemistry#syntheticchemistry#methodology#naturalproducts#instascience#instachemistry#research#lab#gradschool#gradlife#phd#uottawa#graduatestudies#scienceresearch